Cannabis and its derivatives have been consumed by humans for centuries, in the past couple of decades scientists have been searching for an explanation as to how Cannabis works. Research on the effects of cannabis led to the discovery of an unknown biochemical communication system called The Endocannabinoid System (ECS), which plays a vital role in regulating our physiology, mood and everyday experience. The ECS is found throughout the brain and nervous system and is involved with things like appetite, pain modulation, digestion, reproduction, motor learning, stress, and memory. The discovery of receptors in the brain that respond pharmacologically to cannabis and the identification of endogenous cannabinoid compounds ( anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and their metabolic enzymes) in our own bodies that bind to these receptors advances our understanding of human biology, health and disease.
Cannabinoids are chemical compounds that activate cannabinoid receptors and other receptors in the body. Although, there are over 100 cannabinoids found in hemp and cannabis, the two that have been studied extensively the most are tetrahydrocannabinol (THC) and cannabidiol (CBD)
There are several different types of cannabinoids that the endocannabinoid system can act on:
Endocannabinoid - These are the natural cannabinoids that your body produces on its own
Phytocannabinoid - These are compounds that are produced by hemp and cannabis plants, such as, THC, CBD, CBDA, CBDN, etc.
CB1 Receptor - are typically found in the brain and throughout the nervous system. Cannabinoids that target these receptors can have an effect on motor learning, coordination, pain modulation and metabolism.
When we talk about the significance of cannabidiol (CBD) and the role that cannabinoids play in maintaining and improving our health, we’re referring to their influence on the endocannabinoid system and potentially improving its ability to maintain homeostasis.
Homeostasis refers to any process or reaction that our body utilizes to actively maintain a constant internal environment. In many cases, these efforts to maintain balance are necessary for survival. It has been shown that your endocannabinoid system effects many bodily functions (shown above) and by stimulating your ECS with cannabinoids, such as CBD, eating organic foods and daily exercise can help keep your body in a state of homeostasis.
Study On The Endocannabinoid System: